View this video of Dr David A. Johnson, as he offers his insights into hepatic encephalopathy (HE). He discusses the importance of identifying overt versus minimal HE. Dr Johnson also reviews treatment options, indicating that a new agent (other than lactulose) could potentially increase patient compliance due to less diarrhea. He mentions rifaximin as an alternative. Finally, he reviews the importance of cognitive and psychomotor testing in identifying and following disease progression.